Mutations

Mutations

Basics

Mutations provide unique modifications to your experience, all ranked by their difficulty level, all providing extra Score points at the end of your run. The number of Mutation points you need to take depends on the Mutation Stage you are playing and the Mutators you may select vary in each run.

Stages

— Stage 0: Starts a normal run without any Mutators active.
— Stage 1: Choose Up to 4 Mutators ranking at a total of at least 2 for +20% Experience.
— Stage 2: Choose Up to 5 Mutators ranking at a total of at least 4 for +40% Experience.
— Stage 3: Choose Up to 6 Mutators ranking at a total of at least 7 for +60% Experience.
— Stage 4: Choose Up to 7 Mutators ranking at a total of at least 10 for +80% Experience.
— Stage 5: Choose Up to 8 Mutators ranking at a total of at least 15 for +110% Experience.
— Stage 6: Choose Up to 9 Mutators ranking at a total of at least 20 for +150% Experience.

Mutation Stages are unlocked by successfully completing a run on the previous Mutation Stage.

Mutations

Image	Mutation	Points	Effect
	Adaptation		For each boss defeated enemies start with +1  Power.
	Adaptation+		For each boss defeated enemies start with +2  Power.
	Aggravation		For each boss defeated enemies start with +10  Health.
	Aggravation+		For each boss defeated enemies start with +20  Health.
	Aggravation++		For each boss defeated enemies start with +30  Health.
	Arduous		Before each Boss battle, pick an additional level 2 Mutator.
	Arduous+		Before each Boss battle, pick an additional level 3 Mutator.
	Arduous++		Before each Boss battle, pick an additional level 4 Mutator.
	Arduous+++		Before each Boss battle, pick an additional level 5 Mutator.
	Baneful		On enemy death: Receive 2  Rupture.
	Baneful+		On enemy death: Receive 4  Rupture.
	Bloodletting		5th  Dice rolled each turn receives  Wound.
	Bloodletting+		4th  Dice rolled each turn receives  Wound.
	Bloodletting++		3rd  Dice rolled each turn receives  Wound.
	Boss Toughness		All Boss enemies have +15  Health.
	Boss Toughness+		All Boss enemies have +25  Health.
	Cataclysm		At the end of the 6th turn receive 40  Damage.
	Cataclysm+		At the end of the 5th turn receive 40  Damage.
	Cataclysm++		At the end of the 4th turn receive 40  Damage.
	Cataclysm+++		At the end of the 3rd turn receive 40  Damage.
	Condemnation		Turn 3: Receive 3  Curse.
	Condemnation+		Turn 3: Receive 3  Curse.
	Condemnation++		Turn 1: Receive 3  Curse.
	Decrepit		Turn 2: Receive 1  Sap.
	Decrepit+		Turn 2: Receive 2  Sap.
	Decrepit++		Turn 1: Receive 2  Sap.
	Decrepit+++		Turn 2: Receive 4  Sap.
	Decrepit++++		Turn 1: Receive 4  Sap.
	Deprived		-1  Potion slot.
	Deprived+		-2  Potion slots.
	Diminishment		Every 2nd turn: Remove 1  Charge from leftmost  Spell. If leftmost spell is  Muted,  Broken, or does not use charges (see Encase Azur) the next leftmost spell will be affected. Affects both Restorable and Unrestorable charges.
	Diminishment+		Every turn: Remove 1  Charge from leftmost  Spells. Affects both Restorable and Unrestorable charges.
	Diminishment++		Every 3rd turn: Remove 1  Charge from All  Spells. Affects both Restorable and Unrestorable charges.
	Diminishment+++		Every 2nd turn: Remove 1  Charge from ALL  Spells. Affects both Restorable and Unrestorable charges.
	Elusive Foes		Enemies start with 1  Dodge.
	Engorge		Enemies start with 1  Grow.
	Engorge+		Enemies start with 2  Grow.
	Escalation		Every 2nd turn: Receive 1  Rupture.
	Escalation+		Every turn: Receive 1  Rupture.
	Escalation++		Every 2nd turn: Receive 2  Rupture.
	Escalation+++		Every turn: Receive 2  Rupture.
	Fragile		Start with 30% less max  Health.
	Fragile+		Start with 50% less max  Health.
	Fragile++		Start with 70% less max  Health.
	Frail Fives		On rolled: Receive 1  Sap.
	Fumble		Turn 2: Receive 1  Fumble.
	Fumble+		Turn 1: Receive 1  Fumble.
	Harmful Twos		On rolled: Receive 2  Damage.
	Hush		6th  Spell cast each turn receives 2  Mute.
	Hush+		5th  Spell cast each turn receives 2  Mute.
	Hush++		4th  Spell cast each turn receives 2  Mute.
	Impoverished		-25%  Gold from combat.
	Impoverished+		-50%  Gold from combat.
	Infectious Ones		On rolled: Apply  Infected to random  Spell.
	Inhibition		On 10th  Spell cast each round,  Deplete ALL  Spells.
	Inhibition+		On 8th  Spell cast each round,  Deplete ALL  Spells.
	Inhibition++		On 7th  Spell cast each round,  Deplete ALL  Spells.
	Inhibition+++		On 6th  Spell cast each round,  Deplete ALL  Spells.
	Inhibition++++		On 5th  Spell cast each round,  Deplete ALL  Spells.
	Inhibition+++++		On 4th  Spell cast each round,  Deplete ALL  Spells.
	Irrecoverable		Reduce non-combat Healing by 25%.
	Irrecoverable+		Reduce non-combat Healing by 50%.
	Irrecoverable++		Reduce non-combat Healing by 75%.
	Jinx		Enemies debuffing  Spells hits one additional  Spell.
	Major Vex		Every 5th  Dice rolled receives  Vex.
	Major Vex+		Every 4th  Dice rolled receives  Vex.
	Major Vex++		Every 3rd  Dice rolled receives  Vex.
	Major Vex+++		Every 2nd  Dice rolled receives  Vex.
	Malady		End of each turn, receive 1  Damage for each  Charge remaining on your  Spells.
	Menace		Enemies start with 1  Power.
	Menace+		Enemies start with 2  Power.
	Monster Toughness		All enemies have +6  Health.
	Monster Toughness+		All enemies have +12  Health.
	Obstacle		Turn 3: ALL enemies gain 10  Block.
	Obstacle+		Turn 2: ALL enemies gain 10  Block.
	Obstacle++		Turn 1: ALL enemies gain 10  Block.
	Obstacle+++		Turn 2: ALL enemies gain 20  Block.
	Offering		When entering Portal between acts, choose and disenchant 1  Spell.
	Offering+		When entering Portal between acts, choose and disenchant 2  Spells.
	Penance		Lose 1 max  Health when collecting a  Spell.
	Penance+		Lose 2 max  Health when collecting a  Spell.
	Perforating Sixes		On rolled: Receive 2  Rupture.
	Scarcity		-1 option in drafts.
	Scarcity+		-2 options in drafts.
	Shattered Spellbook		Start with 1 fewer  Spell slot.
	Shattered Spellbook+		Start with 2 fewer  Spell slots.
	Skulk		Enemies start with 4  Shade Armor.
	Spellbreak		Whenever losing 5 or more  Health from a single source, apply  Broken to a single  Spell.
	Spiny		Enemies start with 1  Thorns.
	Spiny+		Enemies start with 2  Thorns.
	Spiny++		Enemies start with 3  Thorns.
	Straining Fours		On rolled: Receive 2  Weak.
	Tempest		End of every 3rd turn: Receive 5  Damage.
	Tempest+		End of every 3rd turn: Receive 10  Damage.
	Tempest++		End of every 2nd turn: Receive 5  Damage.
	Tempest+++		End of every 3rd turn: Receive 20  Damage.
	Tempest++++		End of every 2nd turn: Receive 10  Damage.
	Tempest+++++		End of every turn: Receive 5  Damage.
	Tempest++++++		End of every 2nd turn: Receive 20  Damage.
	Tempest+++++++		End of every turn: Receive 10  Damage.
	Toxic Threes		On rolled: Receive 1  Poison.
	Unrelenting Foes		Turn 1: ALL enemies receive  Undying.
	Unrelenting Foes+		Turn 1 & 2: ALL enemies receive  Undying.
	Unwieldiness		Destroy random  Dice when more you have more than 5.
	Unwieldiness+		Destroy random  Dice when more you have more than 4.
	Unwieldiness++		Destroy random  Dice when more you have more than 3.
	Vitality		End of each round: Heal most damaged enemy for 5  Health.

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