Mutations
Mutations
Basics
Mutations provide unique modifications to your experience, all ranked by their difficulty level, all providing extra Score points at the end of your run. The number of Mutation points you need to take depends on the Mutation Stage you are playing and the Mutators you may select vary in each run.
Stages
— Stage 0: Starts a normal run without any Mutators active.
— Stage 1: Choose Up to 4 Mutators ranking at a total of at least 2 for +20% Experience.
— Stage 2: Choose Up to 5 Mutators ranking at a total of at least 4 for +40% Experience.
— Stage 3: Choose Up to 6 Mutators ranking at a total of at least 7 for +60% Experience.
— Stage 4: Choose Up to 7 Mutators ranking at a total of at least 10 for +80% Experience.
— Stage 5: Choose Up to 8 Mutators ranking at a total of at least 15 for +110% Experience.
— Stage 6: Choose Up to 9 Mutators ranking at a total of at least 20 for +150% Experience.
Mutation Stages are unlocked by successfully completing a run on the previous Mutation Stage.
Mutations
Image | Mutation | Points | Effect |
---|---|---|---|
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Adaptation | ![]() |
For each boss defeated enemies start with +1 ![]() |
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Adaptation+ | ![]() |
For each boss defeated enemies start with +2 ![]() |
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Aggravation | ![]() |
For each boss defeated enemies start with +10 ![]() |
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Aggravation+ | ![]() |
For each boss defeated enemies start with +20 ![]() |
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Aggravation++ | ![]() |
For each boss defeated enemies start with +30 ![]() |
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Arduous | ![]() |
Before each Boss battle, pick an additional level 2 Mutator. |
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Arduous+ | ![]() |
Before each Boss battle, pick an additional level 3 Mutator. |
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Arduous++ | ![]() |
Before each Boss battle, pick an additional level 4 Mutator. |
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Arduous+++ | ![]() |
Before each Boss battle, pick an additional level 5 Mutator. |
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Baneful | ![]() |
On enemy death: Receive 2 ![]() |
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Baneful+ | ![]() |
On enemy death: Receive 4 ![]() |
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Bloodletting | ![]() |
5th ![]() ![]() |
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Bloodletting+ | ![]() |
4th ![]() ![]() |
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Bloodletting++ | ![]() |
3rd ![]() ![]() |
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Boss Toughness | ![]() |
All Boss enemies have +15 ![]() |
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Boss Toughness+ | ![]() |
All Boss enemies have +25 ![]() |
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Cataclysm | ![]() |
At the end of the 6th turn receive 40 ![]() |
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Cataclysm+ | ![]() |
At the end of the 5th turn receive 40 ![]() |
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Cataclysm++ | ![]() |
At the end of the 4th turn receive 40 ![]() |
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Cataclysm+++ | ![]() |
At the end of the 3rd turn receive 40 ![]() |
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Condemnation | ![]() |
Turn 3: Receive 3 ![]() |
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Condemnation+ | ![]() |
Turn 3: Receive 3 ![]() |
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Condemnation++ | ![]() |
Turn 1: Receive 3 ![]() |
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Decrepit | ![]() |
Turn 2: Receive 1 ![]() |
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Decrepit+ | ![]() |
Turn 2: Receive 2 ![]() |
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Decrepit++ | ![]() |
Turn 1: Receive 2 ![]() |
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Decrepit+++ | ![]() |
Turn 2: Receive 4 ![]() |
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Decrepit++++ | ![]() |
Turn 1: Receive 4 ![]() |
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Deprived | ![]() |
-1 ![]() |
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Deprived+ | ![]() |
-2 ![]() |
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Diminishment | ![]() |
Every 2nd turn: Remove 1 ![]() ![]() If leftmost spell is ![]() ![]() Affects both ![]() ![]() |
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Diminishment+ | ![]() |
Every turn: Remove 1 ![]() ![]() Affects both ![]() ![]() |
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Diminishment++ | ![]() |
Every 3rd turn: Remove 1 ![]() ![]() Affects both ![]() ![]() |
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Diminishment+++ | ![]() |
Every 2nd turn: Remove 1 ![]() ![]() Affects both ![]() ![]() |
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Elusive Foes | ![]() |
Enemies start with 1 ![]() |
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Engorge | ![]() |
Enemies start with 1 ![]() |
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Engorge+ | ![]() |
Enemies start with 2 ![]() |
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Escalation | ![]() |
Every 2nd turn: Receive 1 ![]() |
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Escalation+ | ![]() |
Every turn: Receive 1 ![]() |
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Escalation++ | ![]() |
Every 2nd turn: Receive 2 ![]() |
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Escalation+++ | ![]() |
Every turn: Receive 2 ![]() |
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Fragile | ![]() |
Start with 30% less max ![]() |
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Fragile+ | ![]() |
Start with 50% less max ![]() |
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Fragile++ | ![]() |
Start with 70% less max ![]() |
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Frail Fives | ![]() |
On ![]() ![]() |
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Fumble | ![]() |
Turn 2: Receive 1 ![]() |
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Fumble+ | ![]() |
Turn 1: Receive 1 ![]() |
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Harmful Twos | ![]() |
On ![]() ![]() |
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Hush | ![]() |
6th ![]() ![]() |
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Hush+ | ![]() |
5th ![]() ![]() |
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Hush++ | ![]() |
4th ![]() ![]() |
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Impoverished | ![]() |
-25% ![]() |
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Impoverished+ | ![]() |
-50% ![]() |
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Infectious Ones | ![]() |
On ![]() ![]() ![]() |
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Inhibition | ![]() |
On 10th ![]() ![]() ![]() |
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Inhibition+ | ![]() |
On 8th ![]() ![]() ![]() |
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Inhibition++ | ![]() |
On 7th ![]() ![]() ![]() |
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Inhibition+++ | ![]() |
On 6th ![]() ![]() ![]() |
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Inhibition++++ | ![]() |
On 5th ![]() ![]() ![]() |
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Inhibition+++++ | ![]() |
On 4th ![]() ![]() ![]() |
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Irrecoverable | ![]() |
Reduce non-combat Healing by 25%. |
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Irrecoverable+ | ![]() |
Reduce non-combat Healing by 50%. |
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Irrecoverable++ | ![]() |
Reduce non-combat Healing by 75%. |
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Jinx | ![]() |
Enemies debuffing ![]() ![]() |
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Major Vex | ![]() |
Every 5th ![]() ![]() |
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Major Vex+ | ![]() |
Every 4th ![]() ![]() |
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Major Vex++ | ![]() |
Every 3rd ![]() ![]() |
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Major Vex+++ | ![]() |
Every 2nd ![]() ![]() |
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Malady | ![]() |
End of each turn, receive 1 ![]() ![]() ![]() |
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Menace | ![]() |
Enemies start with 1 ![]() |
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Menace+ | ![]() |
Enemies start with 2 ![]() |
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Monster Toughness | ![]() |
All enemies have +6 ![]() |
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Monster Toughness+ | ![]() |
All enemies have +12 ![]() |
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Obstacle | ![]() |
Turn 3: ALL enemies gain 10 ![]() |
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Obstacle+ | ![]() |
Turn 2: ALL enemies gain 10 ![]() |
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Obstacle++ | ![]() |
Turn 1: ALL enemies gain 10 ![]() |
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Obstacle+++ | ![]() |
Turn 2: ALL enemies gain 20 ![]() |
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Offering | ![]() |
When entering Portal between acts, choose and disenchant 1 ![]() |
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Offering+ | ![]() |
When entering Portal between acts, choose and disenchant 2 ![]() |
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Penance | ![]() |
Lose 1 max ![]() ![]() |
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Penance+ | ![]() |
Lose 2 max ![]() ![]() |
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Perforating Sixes | ![]() |
On ![]() ![]() |
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Scarcity | ![]() |
-1 option in drafts. |
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Scarcity+ | ![]() |
-2 options in drafts. |
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Shattered Spellbook | ![]() |
Start with 1 fewer ![]() |
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Shattered Spellbook+ | ![]() |
Start with 2 fewer ![]() |
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Skulk | ![]() |
Enemies start with 4 ![]() |
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Spellbreak | ![]() |
Whenever losing 5 or more ![]() ![]() ![]() |
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Spiny | ![]() |
Enemies start with 1 ![]() |
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Spiny+ | ![]() |
Enemies start with 2 ![]() |
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Spiny++ | ![]() |
Enemies start with 3 ![]() |
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Straining Fours | ![]() |
On ![]() ![]() |
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Tempest | ![]() |
End of every 3rd turn: Receive 5 ![]() |
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Tempest+ | ![]() |
End of every 3rd turn: Receive 10 ![]() |
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Tempest++ | ![]() |
End of every 2nd turn: Receive 5 ![]() |
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Tempest+++ | ![]() |
End of every 3rd turn: Receive 20 ![]() |
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Tempest++++ | ![]() |
End of every 2nd turn: Receive 10 ![]() |
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Tempest+++++ | ![]() |
End of every turn: Receive 5 ![]() |
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Tempest++++++ | ![]() |
End of every 2nd turn: Receive 20 ![]() |
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Tempest+++++++ | ![]() |
End of every turn: Receive 10 ![]() |
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Toxic Threes | ![]() |
On ![]() ![]() |
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Unrelenting Foes | ![]() |
Turn 1: ALL enemies receive ![]() |
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Unrelenting Foes+ | ![]() |
Turn 1 & 2: ALL enemies receive ![]() |
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Unwieldiness | ![]() |
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Unwieldiness+ | ![]() |
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Unwieldiness++ | ![]() |
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Vitality | ![]() |
End of each round: Heal most damaged enemy for 5 ![]() |